PhytophthoraV1, Main, Exploration, bibRecord, 000923

Signatures of selection and host-adapted gene expression of the Phytophthora infestans RNA silencing suppressor PSR2.

Identifieur interne : 000923 ( Main/Exploration ); précédent : 000922; suivant : 000924

Signatures of selection and host-adapted gene expression of the Phytophthora infestans RNA silencing suppressor PSR2.

Auteurs : Sophie De Vries [Allemagne] ; Janina K. Von Dahlen [Allemagne] ; Constanze Uhlmann [Allemagne] ; Anika Schnake [Allemagne] ; Thorsten Kloesges [Allemagne] ; Laura E. Rose [Allemagne]

Source :

Molecular plant pathology [ 1364-3703 ] ; 2017.

RBID : pubmed:27503598

Descripteurs français

English descriptors

KwdEn :
- Amino Acids (genetics), Gene Expression Profiling (MeSH), Gene Expression Regulation (MeSH), Genes, Suppressor (MeSH), Host Specificity (MeSH), Host-Pathogen Interactions (genetics), Phytophthora infestans (genetics), Plant Diseases (microbiology), Polymorphism, Genetic (MeSH), Protein Structure, Secondary (MeSH), RNA Interference (MeSH), Solanum (microbiology), Species Specificity (MeSH).
MESH :
- chemical , genetics : Amino Acids.
- genetics : Host-Pathogen Interactions, Phytophthora infestans.
- microbiology : Plant Diseases, Solanum.
- Gene Expression Profiling, Gene Expression Regulation, Genes, Suppressor, Host Specificity, Polymorphism, Genetic, Protein Structure, Secondary, RNA Interference, Species Specificity.

Abstract

Phytophthora infestans is a devastating pathogen in agricultural systems. Recently, an RNA silencing suppressor (PSR2, 'Phytophthora suppressor of RNA silencing 2') has been described in P. infestans. PSR2 has been shown to increase the virulence of Phytophthora pathogens on their hosts. This gene is one of the few effectors present in many economically important Phytophthora species. In this study, we investigated: (i) the evolutionary history of PSR2 within and between species of Phytophthora; and (ii) the interaction between sequence variation, gene expression and virulence. In P. infestans, the highest PiPSR2 expression was correlated with decreased symptom expression. The highest gene expression was observed in the biotrophic phase of the pathogen, suggesting that PSR2 is important during early infection. Protein sequence conservation was negatively correlated with host range, suggesting host range as a driver of PSR2 evolution. Within species, we detected elevated amino acid variation, as observed for other effectors; however, the frequency spectrum of the mutations was inconsistent with strong balancing selection. This evolutionary pattern may be related to the conservation of the host target(s) of PSR2 and the absence of known corresponding R genes. In summary, our study indicates that PSR2 is a conserved effector that acts as a master switch to modify plant gene regulation early during infection for the pathogen's benefit. The conservation of PSR2 and its important role in virulence make it a promising target for pathogen management.

DOI: 10.1111/mpp.12465
PubMed: 27503598
PubMed Central: PMC6638260

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<term>Gene Expression Profiling (MeSH)</term>
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<term>Genes, Suppressor (MeSH)</term>
<term>Host Specificity (MeSH)</term>
<term>Host-Pathogen Interactions (genetics)</term>
<term>Phytophthora infestans (genetics)</term>
<term>Plant Diseases (microbiology)</term>
<term>Polymorphism, Genetic (MeSH)</term>
<term>Protein Structure, Secondary (MeSH)</term>
<term>RNA Interference (MeSH)</term>
<term>Solanum (microbiology)</term>
<term>Species Specificity (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Acides aminés (génétique)</term>
<term>Analyse de profil d'expression de gènes (MeSH)</term>
<term>Gènes suppresseurs (MeSH)</term>
<term>Interactions hôte-pathogène (génétique)</term>
<term>Interférence par ARN (MeSH)</term>
<term>Maladies des plantes (microbiologie)</term>
<term>Phytophthora infestans (génétique)</term>
<term>Polymorphisme génétique (MeSH)</term>
<term>Régulation de l'expression des gènes (MeSH)</term>
<term>Solanum (microbiologie)</term>
<term>Spécificité d'espèce (MeSH)</term>
<term>Spécificité d'hôte (MeSH)</term>
<term>Structure secondaire des protéines (MeSH)</term>
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<term>Interactions hôte-pathogène</term>
<term>Phytophthora infestans</term>
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<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Maladies des plantes</term>
<term>Solanum</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Plant Diseases</term>
<term>Solanum</term>
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<term>Gene Expression Regulation</term>
<term>Genes, Suppressor</term>
<term>Host Specificity</term>
<term>Polymorphism, Genetic</term>
<term>Protein Structure, Secondary</term>
<term>RNA Interference</term>
<term>Species Specificity</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term>
<term>Gènes suppresseurs</term>
<term>Interférence par ARN</term>
<term>Polymorphisme génétique</term>
<term>Régulation de l'expression des gènes</term>
<term>Spécificité d'espèce</term>
<term>Spécificité d'hôte</term>
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<front><div type="abstract" xml:lang="en">Phytophthora infestans is a devastating pathogen in agricultural systems. Recently, an RNA silencing suppressor (PSR2, 'Phytophthora suppressor of RNA silencing 2') has been described in P. infestans. PSR2 has been shown to increase the virulence of Phytophthora pathogens on their hosts. This gene is one of the few effectors present in many economically important Phytophthora species. In this study, we investigated: (i) the evolutionary history of PSR2 within and between species of Phytophthora; and (ii) the interaction between sequence variation, gene expression and virulence. In P. infestans, the highest PiPSR2 expression was correlated with decreased symptom expression. The highest gene expression was observed in the biotrophic phase of the pathogen, suggesting that PSR2 is important during early infection. Protein sequence conservation was negatively correlated with host range, suggesting host range as a driver of PSR2 evolution. Within species, we detected elevated amino acid variation, as observed for other effectors; however, the frequency spectrum of the mutations was inconsistent with strong balancing selection. This evolutionary pattern may be related to the conservation of the host target(s) of PSR2 and the absence of known corresponding R genes. In summary, our study indicates that PSR2 is a conserved effector that acts as a master switch to modify plant gene regulation early during infection for the pathogen's benefit. The conservation of PSR2 and its important role in virulence make it a promising target for pathogen management.</div>
</front>
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<DateCompleted><Year>2017</Year>
<Month>06</Month>
<Day>19</Day>
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<Month>02</Month>
<Day>25</Day>
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<Title>Molecular plant pathology</Title>
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<ArticleTitle>Signatures of selection and host-adapted gene expression of the Phytophthora infestans RNA silencing suppressor PSR2.</ArticleTitle>
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<Abstract><AbstractText>Phytophthora infestans is a devastating pathogen in agricultural systems. Recently, an RNA silencing suppressor (PSR2, 'Phytophthora suppressor of RNA silencing 2') has been described in P. infestans. PSR2 has been shown to increase the virulence of Phytophthora pathogens on their hosts. This gene is one of the few effectors present in many economically important Phytophthora species. In this study, we investigated: (i) the evolutionary history of PSR2 within and between species of Phytophthora; and (ii) the interaction between sequence variation, gene expression and virulence. In P. infestans, the highest PiPSR2 expression was correlated with decreased symptom expression. The highest gene expression was observed in the biotrophic phase of the pathogen, suggesting that PSR2 is important during early infection. Protein sequence conservation was negatively correlated with host range, suggesting host range as a driver of PSR2 evolution. Within species, we detected elevated amino acid variation, as observed for other effectors; however, the frequency spectrum of the mutations was inconsistent with strong balancing selection. This evolutionary pattern may be related to the conservation of the host target(s) of PSR2 and the absence of known corresponding R genes. In summary, our study indicates that PSR2 is a conserved effector that acts as a master switch to modify plant gene regulation early during infection for the pathogen's benefit. The conservation of PSR2 and its important role in virulence make it a promising target for pathogen management.</AbstractText>
<CopyrightInformation>© 2016 The Authors. Molecular Plant Pathology Published by British Society for Plant Pathology and John Wiley & Sons Ltd.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>de Vries</LastName>
<ForeName>Sophie</ForeName>
<Initials>S</Initials>
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<AffiliationInfo><Affiliation>Institute of Population Genetics, Heinrich-Heine University Duesseldorf, Duesseldorf, 40225, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>iGRAD-Plant Graduate School, Heinrich-Heine University Duesseldorf, Duesseldorf, 40225, Germany.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>von Dahlen</LastName>
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<Author ValidYN="Y"><LastName>Rose</LastName>
<ForeName>Laura E</ForeName>
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Signatures of selection and host-adapted gene expression of the Phytophthora infestans RNA silencing suppressor PSR2.

Signatures of selection and host-adapted gene expression of the Phytophthora infestans RNA silencing suppressor PSR2.

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